The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages
The control of self-renewal and differentiation of neural stem and progenitor cells is a crucial issue in stem cell and cancer biology.Drosophila type II neuroblast lineages are prone to developing impaired neuroblast homeostasis if the limited self-renewing potential of intermediate neural progenitors (INPs) is unrestrained.Here, we demonstrate th